Robert W Keane Selected Research

Inflammasomes

1/2022	Mechanism of action of IC 100, a humanized IgG4 monoclonal antibody targeting apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC).
1/2021	Hyperoxia-activated circulating extracellular vesicles induce lung and brain injury in neonatal rats.
1/2021	Enoxaparin Attenuates Acute Lung Injury and Inflammasome Activation after Traumatic Brain Injury.
1/2021	Tumor necrosis factor-alpha and interferon-gamma induce inflammasome-mediated corneal endothelial cell death.
11/2020	ASC, IL-18 and Galectin-3 as Biomarkers of Non-Alcoholic Steatohepatitis: A Proof of Concept Study.
9/2020	Role of inflammasomes in multiple sclerosis and their potential as therapeutic targets.
6/2020	The Inflammasome Adaptor Protein ASC in Mild Cognitive Impairment and Alzheimer's Disease.
5/2020	IC100: a novel anti-ASC monoclonal antibody improves functional outcomes in an animal model of multiple sclerosis.
1/2020	The Inflammasome Signaling Proteins ASC and IL-18 as Biomarkers of Psoriasis.
1/2020	Neural-respiratory inflammasome axis in traumatic brain injury.

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Robert W Keane Research Topics

Disease

20	Inflammation (Inflammations) 05/2022 - 12/2004
15	Traumatic Brain Injuries (Traumatic Brain Injury) 05/2022 - 12/2004
12	Spinal Cord Injuries (Spinal Cord Injury) 01/2018 - 09/2002
6	Stroke (Strokes) 10/2022 - 03/2009
6	Wounds and Injuries (Trauma) 01/2016 - 03/2008
5	Multiple Sclerosis 09/2020 - 01/2016
4	Lung Injury 01/2021 - 01/2017
3	Infections 01/2022 - 05/2014
3	Cognitive Dysfunction 06/2020 - 12/2011
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 05/2020 - 01/2016
3	Brain Injuries (Brain Injury) 01/2019 - 01/2016
3	Neuroinflammatory Diseases 01/2016 - 04/2014
3	Porcine Reproductive and Respiratory Syndrome (PRRS) 08/2014 - 07/2013
3	Contusions 03/2012 - 09/2002
2	Acute Lung Injury 01/2021 - 01/2018
2	Alzheimer Disease (Alzheimer's Disease) 06/2020 - 04/2014
2	Disease Progression 05/2020 - 01/2018
2	Hyperoxia 01/2019 - 01/2017
2	Brain Ischemia (Cerebral Ischemia) 01/2018 - 03/2009
2	Melanoma (Melanoma, Malignant) 04/2014 - 03/2012
2	Ischemia 01/2013 - 03/2009
2	Hypothermia 10/2012 - 10/2006
1	Ischemic Stroke 10/2022
1	Lupus Nephritis 01/2022
1	Diabetic Nephropathies (Diabetic Nephropathy) 01/2022
1	Liver Diseases (Liver Disease) 11/2020
1	Alcoholic Fatty Liver 11/2020
1	Ventilator-Induced Lung Injury 01/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2020
1	Disseminated Intravascular Coagulation 01/2020
1	Central Nervous System Diseases (CNS Diseases) 01/2020
1	Psoriatic Arthritis 01/2020
1	COVID-19 01/2020
1	Bronchopulmonary Dysplasia 01/2017
1	Vascular Remodeling 01/2017
1	Encephalomyelitis (Myeloencephalitis) 05/2014
1	Immune System Diseases (Immune Disorders) 05/2014
1	Central Nervous System Infections (Central Nervous System Infection) 04/2014
1	AIDS-Related Complex (ARC) 09/2013
1	Pressure Ulcer (Bedsore) 01/2013

Drug/Important Bio-Agent (IBA)

37	InflammasomesIBA 01/2022 - 03/2008
21	Proteins (Proteins, Gene)FDA Link 05/2022 - 10/2006
11	CytokinesIBA 10/2022 - 03/2008
8	Biomarkers (Surrogate Marker)IBA 10/2022 - 01/2018
7	InterleukinsIBA 01/2021 - 03/2009
6	Interleukin-18 (Interleukin 18)IBA 11/2020 - 03/2009
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 12/2004
4	NLR ProteinsIBA 01/2016 - 07/2013
3	Type I Tumor Necrosis Factor ReceptorsIBA 01/2020 - 10/2006
3	Pattern Recognition ReceptorsIBA 08/2014 - 07/2013
3	CaspasesIBA 02/2012 - 09/2002
3	LigandsIBA 05/2007 - 12/2004
2	Interleukin-6 (Interleukin 6)IBA 10/2022 - 01/2020
2	Multiprotein ComplexesIBA 01/2022 - 01/2016
2	Enoxaparin (Lovenox)FDA LinkGeneric 01/2021 - 01/2020
2	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 01/2021 - 01/2020
2	Monoclonal AntibodiesIBA 05/2020 - 01/2020
2	Interleukin-1 (Interleukin 1)IBA 01/2016 - 08/2011
2	NucleotidesIBA 01/2016 - 12/2011
2	Probenecid (Benemid)FDA LinkGeneric 04/2014 - 12/2012
2	DNA (Deoxyribonucleic Acid)IBA 04/2014 - 03/2014
2	Adenosine Triphosphate (ATP)IBA 03/2014 - 07/2013
2	Peptides (Polypeptides)IBA 09/2013 - 09/2002
2	Biological ProductsIBA 09/2013 - 03/2006
2	X-Linked Inhibitor of Apoptosis ProteinIBA 07/2009 - 10/2006
2	Neutralizing AntibodiesIBA 07/2009 - 03/2009
2	Interleukin-1beta (Interleukin 1 beta)IBA 07/2009 - 03/2008
2	NF-kappa B (NF-kB)IBA 10/2006 - 12/2004
2	I-kappa B KinaseIBA 10/2006 - 12/2004
1	Interleukin-16 (Interleukin 16)IBA 10/2022
1	Interleukin-2 (IL2)IBA 10/2022
1	Vascular Endothelial Growth Factor CIBA 10/2022
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2022
1	Interleukin-4 (Interleukin 4)IBA 10/2022
1	Interleukin-8 (Interleukin 8)IBA 10/2022
1	Interleukin-13IBA 10/2022
1	Galectin 3 (LGALS3)IBA 11/2020
1	Dacarbazine (DIC)FDA LinkGeneric 01/2020
1	Type II Tumor Necrosis Factor ReceptorsIBA 01/2020
1	interleukin-1beta-converting enzyme inhibitorIBA 01/2019
1	N-acetyl-tyrosyl-valyl-alanyl-aspartyl chloromethyl ketoneIBA 01/2019
1	salicylhydroxamic acid (SHAM)IBA 01/2018
1	NSC 23766IBA 01/2017
1	Saline SolutionIBA 01/2017
1	Caspase 1 (ICE Protease)IBA 01/2016
1	Toll-Like Receptors (Toll-Like Receptor)IBA 08/2014
1	Pathogen-Associated Molecular Pattern MoleculesIBA 08/2014
1	C-Type Lectins (C-Type Lectin)IBA 08/2014
1	PyrinIBA 05/2014
1	Pertussis ToxinIBA 05/2014
1	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 09/2013
1	Neuropeptide YIBA 09/2013
1	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 09/2013
1	Janus KinasesIBA 09/2013
1	AdipokinesIBA 09/2013
1	Leptin ReceptorsIBA 09/2013
1	rho-Associated KinasesIBA 09/2013

Therapy/Procedure

4	Therapeutics 01/2020 - 12/2012
2	Intraperitoneal Injections 01/2019 - 01/2017
1	Artificial Respiration (Mechanical Ventilation) 01/2020